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Hydroxychloroquine in Coronavirus Disease 2019 Patients: What Still Needs to Be Known About the Kinetics.
Martin-Blondel, Guillaume; Ruiz, Stéphanie; Murris, Marlène; Faguer, Stanilas; Duhalde, Véronigue; Eyvrard, Frédéric; Izopet, Jacques; Mansuy, Jean-Michel; Rolland, Yves; Delavigne, Karen; Guimbaud, Rosine; Pugnet, Grégory; Conil, Jean-Marie; Georges, Bernard; Delobel, Pierre; Minville, Vincent; Silva Sifontes, Stein; Concordet, Didier; Gandia, Peggy.
Clin Infect Dis ; 71(11): 2962-2964, 2020 12 31.
Article in English | MEDLINE | ID: covidwho-1003524

ABSTRACT

Different dosage regimens of hydroxychloroquine are used to manage coronavirus disease 2019 (COVID-19) patients, without information on the pharmacokinetics in this population. Blood samples (n = 101) were collected from 57 COVID-19 patients for 7 days, and concentrations were compared with simulated kinetic profiles. Hydroxychloroquine exposure is low and cannot be predicted by other populations.


Subject(s)
Antiviral Agents , COVID-19 Drug Treatment , Antiviral Agents/therapeutic use , Humans , Hydroxychloroquine/therapeutic use , Kinetics , SARS-CoV-2
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